Single-cell sequencing reveals intracranial microvasculature-derived CXCL12 promotes CD8+ T-cell infiltration and blood–brain barrier dysfunction after subarachnoid hemorrhage in mice
This study suggests that, following SAH, both pericytes and endothelial cells may contribute to immune regulation by producing CXCL12, which promotes CD8⁺ T-cell infiltration into the brain. This mechanism may play a role in BBB disruption and neurological dysfunction. Targeting the CXCL12-CXCR4 axis could offer a potential approach for mitigating immune-mediated injury after SAH.
Authors
- Hua Feng (ORCID: https://orcid.org/0000-0003-4489-9217)
- Zhi Chen (ORCID: https://orcid.org/0000-0002-8404-4937)
- Xuyang Zhang (ORCID: https://orcid.org/0000-0001-8118-8487)
- Yuanshu Li (ORCID: https://orcid.org/0000-0001-7890-9239)
- Peiwen Guo (ORCID: https://orcid.org/0000-0001-8029-9476)
- Jiru Zhou (ORCID: https://orcid.org/0000-0002-7100-9665)
- Mingxu Duan
- Xufang Ru (ORCID: https://orcid.org/0000-0001-5732-2092)
- Yujie Chen (ORCID: https://orcid.org/0000-0002-9905-9138)
- Weina Li (ORCID: https://orcid.org/0000-0003-3198-1115)
- Wenyan Li (ORCID: https://orcid.org/0000-0003-1861-6383)
- Jie Lin (ORCID: https://orcid.org/0000-0001-6055-5903)
- Ya Xu
- Wenbo Kang
Institutions
- Army Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Southwest Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s12974-025-03444-0
- Citations
- 6
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.05
Funders
- Chongqing Municipal Health Commission
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing