The absence of both RIBC1 and RIBC2 induces decreased sperm motility and litter size in male mice
Both RIBC1 and RIBC2 are not significant for maintaining the axonemal structure in mouse spermatozoa, but both proteins function cooperatively in sperm motility. This result may indicate that minor structural changes due to RIBC protein absence are not detected at the TEM level, and RIBC2 function depends on RIBC1 in sperm motility. We think that reduced litter size in Ribc1/2 DKO mice is caused by reduced sperm motility due to minor structural abnormalities caused by the loss of two RIBC proteins.
Authors
- Daisuke Mashiko (ORCID: https://orcid.org/0000-0003-3927-3076)
- Kento Katsuma
- Keisuke Shimada (ORCID: https://orcid.org/0000-0003-3739-7163)
- Yuki Kaneda (ORCID: https://orcid.org/0000-0001-6300-4234)
- Haruhiko Miyata (ORCID: https://orcid.org/0000-0003-4758-5803)
- Rie Iida‐Norita (ORCID: https://orcid.org/0000-0003-0104-1974)
- Masahito Ikawa (ORCID: https://orcid.org/0000-0001-9859-6217)
- Shingo Tonai
Institutions
- Ube Frontier University (JP)
- The University of Tokyo (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Andrology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1111/andr.70045
- Citations
- 1
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Takeda Science Foundation
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development