Deletion of <i>RAP1</i> affects iron homeostasis, azole resistance, and virulence in <i>Candida albicans</i>
<i>Candida albicans</i> is an important pathogenic fungus that can cause superficial to life-threatening infections. Iron is essential for almost all organisms, yet it is highly restricted within the human host to defend against pathogens. To grow and survive in the iron-limited host environment, <i>C. albicans</i> has evolved multiple iron acquisition mechanisms. Understanding the regulation of iron homeostasis is, therefore, critical for elucidating <i>C. albicans</i> pathogenesis and virulence. This study explores the novel functions of <i>C. albicans</i> Rap1, with a focus on its contribution to iron acquisition and utilization. Our findings further highlight how iron availability impacts antifungal resistance and virulence through Rap1, providing insight into the complex iron regulatory machinery of <i>C. albicans</i>.
Authors
- Chung‐Yu Lan (ORCID: https://orcid.org/0000-0002-1533-3049)
- Hsiu‐Jung Lo (ORCID: https://orcid.org/0000-0001-8864-5214)
- Min-Chi Yang
- Yu‐Shan Chang (ORCID: https://orcid.org/0000-0002-5594-6528)
- I‐Ching Wang (ORCID: https://orcid.org/0000-0003-4398-2975)
- Sey‐En Lin (ORCID: https://orcid.org/0000-0002-8994-9452)
- Chi-Jan Lin (ORCID: https://orcid.org/0000-0002-6873-6570)
- William J. Huang (ORCID: https://orcid.org/0000-0001-9048-4990)
- Kuo‐Yun Tseng (ORCID: https://orcid.org/0009-0003-7131-4744)
- Hsuan‐Yu Chen (ORCID: https://orcid.org/0000-0003-0358-9132)
Institutions
- National Chung Hsing University (TW)
- National Health Research Institutes (TW)
- National Tsing Hua University (TW)
- Czech Academy of Sciences, Institute of Biotechnology (CZ)
- National Taipei University (TW)
Publication Details
- Journal
- mSphere
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1128/msphere.00155-25
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science and Technology Council