LDHA-lactate axis modulates mitophagy inhibiting CSFV replication
This research unveils how CSFV interacts with cellular metabolism through LDHA. By revealing LDHA's dual role and how lactate influences cellular processes during CSFV infection, this study uncovers new pathways for viral replication. These findings not only deepen our understanding of viral-host interactions but also open doors for innovative antiviral strategies centered around manipulating cellular metabolism.
Authors
- Wenhui Zhu (ORCID: https://orcid.org/0000-0001-6767-6302)
- Xinliang Fu (ORCID: https://orcid.org/0000-0002-7741-7387)
- Qi Qiu (ORCID: https://orcid.org/0000-0002-0933-4707)
- Zhanhui Zhang (ORCID: https://orcid.org/0000-0002-9299-0712)
- Shuangqi Fan (ORCID: https://orcid.org/0009-0005-9975-2978)
- Zipeng Luo
- Sen Zeng
- Nan Cao
- Wenjun Liu (ORCID: https://orcid.org/0000-0002-7205-0598)
- Ruibo Zhao (ORCID: https://orcid.org/0000-0002-5172-4696)
- Cheng Fu
- Shuaiqi Zhu (ORCID: https://orcid.org/0009-0006-2706-9675)
Institutions
- South China Agricultural University (CN)
- Zhongkai University of Agriculture and Engineering (CN)
Publication Details
- Journal
- Journal of Virology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1128/jvi.00268-25
- Citations
- 2
- Primary Topic
- Animal Disease Management and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.81