<i>Plasmodium falciparum Kelch-13</i> artemisinin partial resistance markers in Fort Portal, Western Uganda, 2024
In Fort Portal, Uganda, artemisinin resistance-associated mutations in <i>Plasmodium falciparum Kelch13</i> (<i>n</i> = 126) were present in 4.8% (675V, 561H, and 441L). A mutation of unknown relevance, 490T, occurred in 9.5%. <i>PfMDR1</i> variants suggested increased lumefantrine tolerance (N86, 100%). Mutation 500N was absent, and 199S occurred in 12.8%. The latter is of unknown relevance. These data indicate an incipient emergence of artemisinin resistance in a crucial location between Rwandan and Ugandan resistance hotspots and hardly affected DR Congo.
Authors
- Frank P. Mockenhaupt (ORCID: https://orcid.org/0000-0002-8117-5421)
- Patrick Musinguzi (ORCID: https://orcid.org/0000-0003-0992-558X)
- John Rubaihayo (ORCID: https://orcid.org/0000-0002-3421-2242)
- Welmoed van Loon (ORCID: https://orcid.org/0000-0003-3331-3997)
- Emmanuel Mande (ORCID: https://orcid.org/0000-0003-0587-8181)
- Sharon Atukunda
- Emma Schallenberg
- Paul Ngobi
Institutions
- Fort Portal Hospital (UG)
- Mountains of the Moon University (UG)
- Infectious Diseases Institute (UG)
- Center for Global Health (US)
- Makerere University (UG)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1128/aac.01755-24
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Else Kröner-Fresenius-Stiftung