The Vodka Trial: Clinical and Genetic Characteristics of Alcohol Responsiveness in Laryngeal Dystonia
Alcohol responsiveness of LD symptoms is a robust feature related to the genes regulating the GABAergic synapses. This finding provides support for the evaluation of novel oral medications with mechanisms of action similar to alcohol for the treatment of patients with alcohol-responsive dystonia.
Authors
- Kristina Simonyan (ORCID: https://orcid.org/0000-0001-7444-0437)
- Laurie J. Ozelius (ORCID: https://orcid.org/0000-0002-7820-1684)
- Azadeh Hamzehei Sichani (ORCID: https://orcid.org/0000-0001-7253-3277)
- Ayumi Nishiyama (ORCID: https://orcid.org/0000-0002-5229-4296)
- Aloysius Domingo (ORCID: https://orcid.org/0000-0002-1396-3303)
- Lena C. O’Flynn (ORCID: https://orcid.org/0000-0001-6368-0793)
- Rachita Yadav (ORCID: https://orcid.org/0000-0003-2123-5223)
- Madison Hincher
Institutions
- Broad Institute (US)
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Movement Disorders Clinical Practice
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1002/mdc3.70097
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Institutes of Health