Aberrant aging-associated p62 autophagic cascade in biopsied olfactory neuronal cells from patients with psychosis
Sequestosome-1/p62, a key mediator in the clearance of damaged organelles and macromolecules during autophagy, serves as a marker of biological aging. We demonstrate elevated p62 in biopsied neuronal cells in patients with psychosis compared to healthy controls. In healthy controls, p62-indicated biological/autophagic age is positively correlated with chronological age over time, whereas in patients, neuronal p62-indicated biological/autophagic age shows no correlation with chronological age, being significantly higher than chronological age from the onset of the disease.
Authors
- Toshifumi Tomoda (ORCID: https://orcid.org/0000-0003-3587-0914)
- Akira Sawa (ORCID: https://orcid.org/0000-0003-1401-3008)
- Kun Yang (ORCID: https://orcid.org/0000-0002-1060-8082)
- Koko Ishizuka
Institutions
- Centre for Addiction and Mental Health (CA)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- Schizophrenia
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1038/s41537-025-00617-x
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- Canadian Institutes of Health Research
- National Institute of Mental Health
- CIHR Skin Research Training Centre