Linking DNA methylation in brain regions to Alzheimer’s disease risk: a Mendelian randomization study
Our findings highlight brain region-specific DNA methylation as a mediator of genetic risk for ad, offering insights into ad pathogenesis and identifying potential therapeutic targets.
Authors
- Chong Wu (ORCID: https://orcid.org/0000-0002-8400-1785)
- Degui Zhi (ORCID: https://orcid.org/0000-0001-7754-1890)
- Changwei Li (ORCID: https://orcid.org/0000-0002-9203-304X)
- Yaohua Yang (ORCID: https://orcid.org/0000-0002-3815-7172)
- Lang Wu (ORCID: https://orcid.org/0000-0003-4830-7215)
- Youping Deng (ORCID: https://orcid.org/0000-0002-5951-8213)
- Jingjing Zhu
- Yong Wu (ORCID: https://orcid.org/0000-0002-1698-0897)
- Jianyong Wu (ORCID: https://orcid.org/0000-0003-1392-4790)
- Qing Wu (ORCID: https://orcid.org/0000-0003-4679-8903)
- Quan Long (ORCID: https://orcid.org/0000-0003-3795-1873)
- Xingyi Guo (ORCID: https://orcid.org/0000-0001-5269-1294)
- Chao Cheng (ORCID: https://orcid.org/0000-0003-4330-9342)
- Shuai Liu (ORCID: https://orcid.org/0000-0003-2244-2216)
- Dan Zhou (ORCID: https://orcid.org/0000-0002-5313-8164)
- Bingxin Zhao
- Hua Zhong (ORCID: https://orcid.org/0000-0002-9358-1582)
- Zhaoming Wang
Institutions
- University of Hawaiʻi at Mānoa (US)
- St. Jude Children's Research Hospital (US)
- University of Hawaii System (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Calgary (CA)
- Baylor College of Medicine (US)
- Second Affiliated Hospital of Zhejiang University (CN)
- Southwestern Medical Center (US)
- University of Virginia (US)
- The Ohio State University (US)
- Charles R. Drew University of Medicine and Science (US)
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
- Vanderbilt University Medical Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Human Molecular Genetics
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1093/hmg/ddaf053
- Citations
- 3
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 2.42