Linking DNA methylation in brain regions to Alzheimer’s disease risk: a Mendelian randomization study

Our findings highlight brain region-specific DNA methylation as a mediator of genetic risk for ad, offering insights into ad pathogenesis and identifying potential therapeutic targets.

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Publication Details

Journal
Human Molecular Genetics
Published
2025-04-23
DOI
https://doi.org/10.1093/hmg/ddaf053
Citations
3
Primary Topic
Epigenetics and DNA Methylation
Type
article
Field-Weighted Citation Impact
2.42
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article

Linking DNA methylation in brain regions to Alzheimer’s disease risk: a Mendelian randomization study

Chong Wu, Degui Zhi, Changwei Li, Yaohua Yang et al.
3 citations
Human Molecular Genetics
Epigenetics and DNA Methylation
2.42
article

Linking DNA methylation in brain regions to Alzheimer’s disease risk: a Mendelian randomization study

Chong Wu, Degui Zhi, Changwei Li, Yaohua Yang, Lang Wu, Youping Deng, Jingjing Zhu, Yong Wu, Jianyong Wu, Qing Wu, Quan Long, Xingyi Guo, Chao Cheng, Shuai Liu, Dan Zhou, Bingxin Zhao, Hua Zhong, Zhaoming Wang
article en
3 citations

Abstract

Our findings highlight brain region-specific DNA methylation as a mediator of genetic risk for ad, offering insights into ad pathogenesis and identifying potential therapeutic targets.

Human Molecular GeneticsVol. 34(12)
University of Hawaiʻi at Mānoa (US), St. Jude Children's Research Hospital (US), University of Hawaii System (US), The University of Texas MD Anderson Cancer Center (US), University of Calgary (CA), Baylor College of Medicine (US), Second Affiliated Hospital of Zhejiang University (CN), Southwestern Medical Center (US), University of Virginia (US), The Ohio State University (US), Charles R. Drew University of Medicine and Science (US), University of Pennsylvania (US), The University of Texas Southwestern Medical Center (US), Vanderbilt University Medical Center (US), The University of Texas Health Science Center at Houston (US)
Good health and well-being
Openalex Percentile: Top 12%
Epigenetics and DNA Methylation
2.42
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