Hypobaric Conditions in Cabin Altitude Restricted Aeromedical Evacuation Induce Systemic Inflammation Following Porcine Traumatic Brain Injury
The CAR-prescribed cabin altitude of 5000 ft may not be sufficient in ameliorating altitude-induced inflammatory cytokine release following TBI. This altitude effect was not rescued with supplemental oxygen to promote SpO2 of 100%, demonstrating a hypobaric effect independent of altitude-related hypoxia. Further study may focus on delayed AE after injury rather than CAR for early post-injury flight.
Authors
- Adam D Price
- Maia P. Smith (ORCID: https://orcid.org/0000-0002-1154-1158)
- Timothy A. Pritts (ORCID: https://orcid.org/0000-0003-2495-3255)
- Richard Strilka (ORCID: https://orcid.org/0000-0003-2707-7991)
- Matthew R Baucom (ORCID: https://orcid.org/0000-0002-5444-7575)
- Michael D. Goodman (ORCID: https://orcid.org/0000-0001-7218-4855)
- Chad M Archdeacon
- Thomas C Blakeman (ORCID: https://orcid.org/0000-0003-1141-0139)
- Rebecca Schuster
- Chelsea Caskey
- Ellen R Becker
Institutions
- University of Cincinnati (US)
Publication Details
- Journal
- Military Medicine
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1093/milmed/usaf141
- Citations
- 3
- Primary Topic
- High Altitude and Hypoxia
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- U.S. Air Force
- National Institute of General Medical Sciences