TMBIM-2 links neuronal mitochondrial stress to systemic adaptation via calcium signaling
Mitochondrial function is critical for neuronal activity and systemic metabolic adaptation. In this issue, Li et al. (https://doi.org/10.1083/jcb.202408050) identify TMBIM-2 as a key regulator of calcium dynamics, coordinating the neuronal-to-intestinal mitochondrial unfolded protein response (UPRmt), pathogen-induced aversive learning, and aging.
Authors
- Terytty Yang Li (ORCID: https://orcid.org/0000-0003-3684-7935)
- Yu Sun (ORCID: https://orcid.org/0000-0003-2392-2043)
Institutions
- Fudan University (CN)
- State Key Laboratory of Genetic Engineering
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1083/jcb.202503004
- Citations
- 1
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation