Migraine and cardiovascular disease: A two-sample Mendelian randomization study

This study investigates the causal association between migraine and cardiovascular disease from a genetic perspective based on the Mendelian randomization analysis (MR) method. Single nucleotide polymorphism (SNPs) loci were used as genetic instrumental variables (IVs) to analyze potential causal relationships between exposure and outcome factors. The causal association between migraine and cardiovascular disease in terms of prevalence was assessed using inverse variance weighted as the primary MR method. Migraine is negatively associated with coronary artery disease (CAD) when migraine is the exposure and CAD is the outcome (OR = 0.0226, 95% CI = 0.0019-0.2639, P = .0024). CAD was negatively associated with migraine when CAD was the exposure and migraine was the outcome (OR = 0.9950, 95% CI = 0.9922-0.9978). No causal association between other cardiovascular diseases and migraine was found. This study demonstrates a negative causal relationship between CAD and migraine.