Hematopoietic Cell Transplantation in a Patient With X‐Linked Chronic Granulomatous Disease With <scp>McLeod</scp> Phenotype
We were able to safely perform transplantation in a patient with X-CGD and MLS by adding rituximab and depleting RBCs from the donor bone marrow. The long-term impact of HCT on MLS is unclear. However, HCT may improve prognosis and quality of life by reducing recurrent infections caused by X-CGD. Moreover, this HCT method is non-invasive, relatively simple, and easily implementable.
Authors
- Takashi Ishikawa (ORCID: https://orcid.org/0000-0003-0247-7729)
- Kazuhiko Nakabayashi (ORCID: https://orcid.org/0000-0003-2927-0963)
- Kimikazu Matsumoto (ORCID: https://orcid.org/0000-0002-5340-3781)
- Akihiro Iguchi (ORCID: https://orcid.org/0000-0002-1367-3883)
- Yoshihiro Gocho (ORCID: https://orcid.org/0000-0001-8136-0187)
- Daisuke Tomizawa (ORCID: https://orcid.org/0000-0003-1520-7007)
- Kentaro Fujimori (ORCID: https://orcid.org/0000-0002-6136-4903)
- Toshinao Kawai (ORCID: https://orcid.org/0000-0002-4152-9301)
- Toru Uchiyama (ORCID: https://orcid.org/0000-0001-9610-0900)
- Masafumi Onodera (ORCID: https://orcid.org/0000-0001-9449-2066)
- Soichiro Shimizu (ORCID: https://orcid.org/0000-0003-1324-1973)
- Hirotoshi Sakaguchi (ORCID: https://orcid.org/0000-0003-0236-1187)
Institutions
- National Center For Child Health and Development (JP)
Publication Details
- Journal
- Pediatric Transplantation
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1111/petr.70086
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Center for Child Health and Development