The Impact of Brain‐Derived Neurotrophic Factor rs6265 ( <scp>Val66Met</scp> ) Polymorphism on Therapeutic Electrical Stimulation for Peripheral Nerve Regeneration: A Preclinical Study of Therapy–Genotype Interactions
The rs6265 polymorphism influences TES efficacy, highlighting the need for personalized approaches in peripheral nerve injury (PNI) treatment. These findings suggest that genetic screening could optimize therapeutic outcomes. Understanding genetic factors affecting TES response can enhance treatment strategies for PNI, potentially improving patient recovery and reducing outcome variability.
Authors
- Maria J. Quezada (ORCID: https://orcid.org/0000-0001-9120-4970)
- Colin K. Franz (ORCID: https://orcid.org/0000-0003-4546-8638)
- Suning He
- Jordan B. Walters
- Kathy Steece‐Collier (ORCID: https://orcid.org/0000-0002-8137-2310)
- Chas Haynes
- Caryl E. Sortwell (ORCID: https://orcid.org/0000-0003-2571-6753)
- Timothy J. Collier (ORCID: https://orcid.org/0000-0003-0282-8875)
Institutions
- Northwestern University (US)
- Shirley Ryan AbilityLab (US)
- Trinity Health Grand Rapids (US)
- Michigan State University (US)
Publication Details
- Journal
- Muscle & Nerve
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1002/mus.28409
- Citations
- 3
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 2.73
Funders
- Northwestern University
- National Institutes of Health
- Robert H. Lurie Comprehensive Cancer Center
- National Cancer Institute