Vascular-related biological stress, DNA methylation, allostatic load and domain-specific cognition: an integrated machine learning and causal inference approach
Our findings suggest that vascular-related biological stress, DNA methylation and to some extent allostatic load mediate the effects of vascular disease on global cognition and executive function.
Authors
- Olajide Williams (ORCID: https://orcid.org/0000-0002-0210-0078)
- Reem Waziry (ORCID: https://orcid.org/0000-0003-2266-293X)
- Henning W. Tiemeier (ORCID: https://orcid.org/0000-0002-4395-1397)
- Caleb H. Miles (ORCID: https://orcid.org/0000-0002-9792-6699)
Institutions
- Harvard University (US)
- Columbia University (US)
Publication Details
- Journal
- BMC Neurology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s12883-025-04185-6
- Citations
- 2
- Primary Topic
- Cardiovascular Health and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- John D. and Catherine T. MacArthur Foundation
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- National Center for Advancing Translational Sciences