Heart Rate Mystery Unveiled: Sex Differences in Human Sinoatrial Node Genes and Female Tachycardia
The human SAN exhibits region-specific sexual dimorphism in pacemaking gene sets. Higher expression of <i>TBX3</i> and <i>HCN1</i> in female SAN may underlie faster HR and increased susceptibility to inappropriate sinus tachycardia in women, whereas enriched gene sets related to inflammation and collagen biosynthesis in men may predispose them to conduction impairments and atrial fibrillation risk.
Authors
- James J. Kennelly (ORCID: https://orcid.org/0000-0002-7631-5426)
- Vadim V. Fedorov (ORCID: https://orcid.org/0000-0003-1035-4569)
- Bryan A. Whitson (ORCID: https://orcid.org/0000-0003-0040-3638)
- Jichao Zhao (ORCID: https://orcid.org/0000-0003-3303-0401)
- Peter J. Mohler (ORCID: https://orcid.org/0000-0002-7977-8717)
- Roshan Sharma
- Amy Webb (ORCID: https://orcid.org/0000-0001-5503-7300)
- John D. Hummel (ORCID: https://orcid.org/0000-0002-2629-2553)
- Ning Li (ORCID: https://orcid.org/0000-0003-3420-0206)
Institutions
- Auckland Institute of Studies (NZ)
- The Ohio State University Wexner Medical Center (US)
Publication Details
- Journal
- Circulation Arrhythmia and Electrophysiology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1161/circep.124.013534
- Citations
- 5
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 6.94