Drivers of bias in diagnostic test accuracy estimates when using expert panels as a reference standard: a simulation study
Bias in accuracy estimates when using an expert panel will increase if the component reference tests are less accurate. Prevalence, the true value of the index test accuracy, and random or systematic differences between experts can also impact the amount of bias, but the amount and even direction will vary between scenarios.
Authors
- Johannes B. Reitsma (ORCID: https://orcid.org/0000-0003-4026-4345)
- Ewoud Schuit (ORCID: https://orcid.org/0000-0002-9548-3214)
- Lotty Hooft (ORCID: https://orcid.org/0000-0002-7950-2980)
- Kevin Jenniskens (ORCID: https://orcid.org/0000-0003-3724-8424)
- Bas E Kellerhuis (ORCID: https://orcid.org/0009-0006-9996-1419)
- Karel G. M. Moons (ORCID: https://orcid.org/0009-0004-7797-1056)
Institutions
- University Medical Center Utrecht (NL)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s12874-025-02557-7
- Citations
- 4
- Primary Topic
- Meta-analysis and systematic reviews
- Type
- article
- Field-Weighted Citation Impact
- 5.59