Differential responses of lung and intestinal microbiota to SARS-CoV-2 infection: a comparative study of the Wuhan and Omicron strains in K18-hACE2 Tg mice
This study highlights critical differences between the Wuhan strain and Omicron variant in terms of mortality, lung pathology, and microbiota changes, emphasizing the role of the microbiome in influencing disease outcomes. Novel findings include the identification of variant-specific microbiota shifts, which underscore potential microbiome-related mechanisms underlying differences in disease severity. These insights pave the way for future research exploring microbiome-targeted interventions to mitigate the impacts of SARS-CoV-2 and other viral infections.
Authors
- Insu Hwang (ORCID: https://orcid.org/0000-0001-8038-1082)
- Kyun‐Do Kim (ORCID: https://orcid.org/0000-0001-6872-5583)
- Keun Bon Ku (ORCID: https://orcid.org/0000-0003-0870-0995)
- Heung Kyu Lee (ORCID: https://orcid.org/0000-0002-3977-1510)
- Hi Eun Jung (ORCID: https://orcid.org/0000-0001-6501-6810)
- Chae Won Kim (ORCID: https://orcid.org/0000-0002-4875-4501)
Institutions
- Korea Advanced Institute of Science and Technology (KR)
- Korea Research Institute of Chemical Technology (KR)
Publication Details
- Journal
- Laboratory Animal Research
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s42826-025-00241-x
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Research Foundation
- Korea Research Institute of Chemical Technology
- National Research Foundation of Korea