Exhausted natural killer cells in adult IgA vasculitis
Patients with IgAVN exhibited impaired cytotoxic and immunomodulatory functions of NK cells, along with a marked absence of interferon signaling in PBMCs. Further studies are needed to confirm if discrimination of patient subsets based on leukocyte samples might be of clinical use and if deregulated NK function might contribute to the pathogenesis of nephritis in adult IgAV.
Authors
- Emanuela Senjor (ORCID: https://orcid.org/0000-0002-1040-5365)
- Matjaž Hladnik (ORCID: https://orcid.org/0000-0002-7955-2873)
- Matija Bajželj
- Alojzija Hočevar (ORCID: https://orcid.org/0000-0002-7361-6549)
- Snežna Sodin‐Šemrl (ORCID: https://orcid.org/0000-0003-3696-2650)
- Alojz Ihan (ORCID: https://orcid.org/0000-0003-2904-1212)
- Katja Lakota (ORCID: https://orcid.org/0000-0002-8062-7908)
- Janko Kos
- Milica Perišić Nanut (ORCID: https://orcid.org/0000-0003-2314-2733)
- Andreja Nataša Kopitar
- Nika Boštic
Institutions
- University of Primorska (SI)
- University of Ljubljana (SI)
- Ljubljana University Medical Centre (SI)
- Jožef Stefan Institute (SI)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s13075-025-03559-y
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Javna Agencija za Raziskovalno Dejavnost RS