Predicting Inhibitor Development in Hemophilia ‘A’ using Machine Learning: A Comprehensive Approach to Data Preprocessing, Balancing, and Biomarker Identification Using AI on the CHAMP Dataset

This study presents a breakthrough in the early prediction of inhibitor development in Hemophilia 'A' patients, paving the way for personalized and effective treatment programs. The integration of the preprocessing pipeline, Random Forest model, and SHAP analysis offers a novel solution for guiding treatment strategies for HA patients, which could significantly enhance the development of targeted and effective therapies.

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Publication Details

Journal
Current Pharmaceutical Biotechnology
Published
2025-04-23
DOI
https://doi.org/10.2174/0113892010366485250415101928
Citations
1
Primary Topic
Hemophilia Treatment and Research
Type
article
Field-Weighted Citation Impact
1.77
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article

Predicting Inhibitor Development in Hemophilia ‘A’ using Machine Learning: A Comprehensive Approach to Data Preprocessing, Balancing, and Biomarker Identification Using AI on the CHAMP Dataset

Maheshwari Prasad Singh, Vikalp Kumar Singh
1 citations
Current Pharmaceutical Biotechnology
Hemophilia Treatment and Research
1.77
article

Predicting Inhibitor Development in Hemophilia ‘A’ using Machine Learning: A Comprehensive Approach to Data Preprocessing, Balancing, and Biomarker Identification Using AI on the CHAMP Dataset

Maheshwari Prasad Singh, Vikalp Kumar Singh
article en
1 citations

Abstract

This study presents a breakthrough in the early prediction of inhibitor development in Hemophilia 'A' patients, paving the way for personalized and effective treatment programs. The integration of the preprocessing pipeline, Random Forest model, and SHAP analysis offers a novel solution for guiding treatment strategies for HA patients, which could significantly enhance the development of targeted and effective therapies.

Current Pharmaceutical BiotechnologyVol. 26(13)
National Institute of Technology Patna (IN)
Life in Land
Openalex Percentile: Top 17%
Hemophilia Treatment and Research
1.77
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