Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU-005 reduces ex vivo cortical spreading depression
Given the distinct profile of endocannabinoids hydrolases activities between rats and mice in the brain areas associated with migraine, AKU-005 may target multiple endocannabinoid hydrolases to serve as an efficient treatment option for migraine with aura.
Authors
- Tarja Malm (ORCID: https://orcid.org/0000-0002-9530-7472)
- Rashid Giniatullin (ORCID: https://orcid.org/0000-0002-1580-6280)
- Konstantin Ivanov (ORCID: https://orcid.org/0000-0001-6048-0972)
- Raisa Giniatullina
- Adriana Della Pietra
- Marko Lehtonen (ORCID: https://orcid.org/0000-0002-5611-0466)
- Juha R. Savinainen (ORCID: https://orcid.org/0000-0002-1301-9064)
- Flavia Brugia
- Auni Aroviita
Institutions
- University of Eastern Finland (FI)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s10194-025-02030-2
- Citations
- 4
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Itä-Suomen Yliopisto
- Opetushallitus
- OLVI-Säätiö