Mitochondrial transfer drives immune evasion in tumor microenvironment
Tumors subvert T cell metabolism through diverse mechanisms. Ikeda et al. reveal mitochondrial transfer as a tumor-driven immune evasion strategy, where cancer cells deliver dysfunctional mitochondria to T cells, impairing metabolism and inducing exhaustion. These findings highlight mitochondrial dynamics as a promising therapeutic target to improve immunotherapy outcomes.
Authors
- Quazi T.H. Shubhra (ORCID: https://orcid.org/0000-0003-4791-2763)
- Xiaojun Cai (ORCID: https://orcid.org/0000-0002-3399-3067)
- Qiang Cai (ORCID: https://orcid.org/0000-0001-7019-3360)
Institutions
- Wenzhou Medical University (CN)
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- University of Silesia in Katowice (PL)
Publication Details
- Journal
- Trends in cancer
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1016/j.trecan.2025.04.002
- Citations
- 6
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.78