Regulating human oocyte maturation in vitro: a hypothesis based on oocytes retrieved from small antral follicles during ovarian tissue cryopreservation
FSH-induced LHCGR expression, along with FSHR downregulation, is closely linked to oocyte maturation. Reduced GDF9 secretion from oocytes facilitates LHCGR expression on cumulus cells, while FSH and LH collectively induced hormones like inhibin-A, which likely support oocyte maturation.
Authors
- Cristina Subiran Adrados (ORCID: https://orcid.org/0000-0002-3002-9125)
- Linn Salto Mamsen (ORCID: https://orcid.org/0000-0002-8827-7519)
- Claus Yding Andersen (ORCID: https://orcid.org/0000-0001-7681-253X)
- Bhanu Kalra (ORCID: https://orcid.org/0000-0003-3643-8488)
- Jesús Cadenas (ORCID: https://orcid.org/0000-0001-8164-3697)
- Ajay Kumar (ORCID: https://orcid.org/0000-0002-5777-3691)
Institutions
- University of Copenhagen (DK)
- Herlev Hospital (DK)
- Copenhagen University Hospital (DK)
Publication Details
- Journal
- Journal of Assisted Reproduction and Genetics
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1007/s10815-025-03483-9
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Danmarks Frie Forskningsfond
- ReproUnion