Therapy-induced senescent glioblastoma cells sustain a procancer immune microenvironment by activating DDX58-mediated STAT1 signaling
A critical mechanism for the protumor immune microenvironment mediated by therapy-induced senescent glioblastoma cells, the DDX58-STAT1-CSF1 axis, may be a potential therapeutic avenue for alleviating traditional therapy-induced glioblastoma cell senescence.
Authors
- Yiyun Yin (ORCID: https://orcid.org/0009-0008-8926-3638)
- Ruoyu Huang (ORCID: https://orcid.org/0000-0001-5299-2281)
- Fan Wu (ORCID: https://orcid.org/0000-0003-1226-6984)
- Bojun Qiu
- Tao Jiang (ORCID: https://orcid.org/0000-0002-5600-3548)
- Zefan Jing
- Xin Zhang (ORCID: https://orcid.org/0000-0001-5113-1420)
- Yuxin Zhang (ORCID: https://orcid.org/0009-0007-5310-235X)
- Wei Han (ORCID: https://orcid.org/0000-0001-6848-6439)
- Zhixing Wang
- Wanjun Tang
- Zhiyan Sun (ORCID: https://orcid.org/0000-0002-7053-5583)
- Xinrun Wang (ORCID: https://orcid.org/0009-0000-6761-0506)
- Xiaozhong Peng
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Tian Tan Hospital (CN)
- Beijing Institute of Neurosurgery (CN)
- Institute of Laboratory Animal Science (CN)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1093/neuonc/noaf107
- Citations
- 7
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.58