RNA-seq analysis reveals key genes associated with downregulation of APE1 in esophageal squamous cell carcinoma
Knocking out APE1 can affect the function, related pathways, and downstream target gene expression of ESCC cells. APE1 can promote the transcriptional expressions of FN1 and IL6 genes while inhibiting the TNF gene. FN1, TNF, and IL-6 may be potential target genes regulated by APE1 in esophageal cancer.
Authors
- Zefen Xiao (ORCID: https://orcid.org/0000-0003-0503-6814)
- Rui Song (ORCID: https://orcid.org/0000-0001-5503-3246)
- Zongwen Liu (ORCID: https://orcid.org/0000-0002-6434-1643)
- Yong Tai Wang (ORCID: https://orcid.org/0000-0002-3646-8014)
- Mengxi Li (ORCID: https://orcid.org/0000-0002-6859-6088)
- Chen Sun (ORCID: https://orcid.org/0000-0002-5145-1536)
- Lanlan Gan
- Shijia Liu
- Alan Chu (ORCID: https://orcid.org/0000-0002-6669-9649)
Institutions
- Second Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-04-22
- DOI
- https://doi.org/10.3389/fgene.2025.1549371
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00