Comparative evaluation of certain biomarkers emphasizing abnormal GABA inhibitory effect and glutamate excitotoxicity in autism spectrum disorders
These findings support the hypothesis that GABA and glutamate imbalance is central to the pathophysiology of ASD. Significant disruptions in neurotransmitter signaling and chloride homeostasis, particularly in severe cases, provide insights into the neurobiological mechanisms of ASD. Restoring the GABA-glutamate balance could be an effective therapeutic strategy for ASD, warranting further research into these biochemical pathways for targeted treatments.
Authors
- Afaf El‐Ansary (ORCID: https://orcid.org/0000-0002-1404-5248)
- Mona Alonazi (ORCID: https://orcid.org/0000-0002-9430-7980)
- Altaf Alabdali
- Abir Ben Bacha (ORCID: https://orcid.org/0000-0001-6372-7483)
- Abdullah Saleh Alanazi (ORCID: https://orcid.org/0009-0001-2327-7032)
- Laila Al‐Ayadhi (ORCID: https://orcid.org/0000-0003-3269-0416)
Institutions
- Umm al-Qura University (SA)
- King Saud University (SA)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-04-22
- DOI
- https://doi.org/10.3389/fpsyt.2025.1562631
- Citations
- 5
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 7.16
Funders
- King Abdulaziz City for Science and Technology