Abstract 1078: Enhancing reusability and adoption of cancer research tools: Development of the Cancer Complexity Toolkit

Abstract The Cancer Complexity Knowledge Portal (CCKP) is an open-access data repository that stores and shares resources from multiple cancer research programs. Maintained by Sage Bionetworks, in collaboration with The Multi-Consortia Coordinating (MC2) Center, which supports six NCI Division of Cancer Biology (DCB) funded programs made up of interdisciplinary communities of scientists, the CCKP centralizes access to cancer research tools and data, improving their discoverability and reuse.Reusing tools has proven to be challenging for various reasons. Therefore, we aim to enhance the reusability of the tools available on CCKP. To achieve this, we are designing and implementing a Cancer Complexity Toolkit to validate tool reusability and increase their adoption. Building on existing efforts to curate tools generated by the cancer research community, the 'Cancer Complexity Toolkit' aims to achieve three key objectives: (1) enhancing the discovery and reuse of cancer research tools through rich metadata and standardized evaluation frameworks, (2) creating a catalog of cancer research-focused tools to improve accessibility and confidence in their use, and (3) enabling standardized reporting and validation of tool functionality. Ultimately, we aim to provide a robust platform for discovering, validating, and integrating computational tools in cancer research.To achieve these goals, we are (1) refining a standardized schema to capture metadata on tool parameters and usage, (2) building infrastructure for automated checks to assess documentation, test coverage, and community metrics, and (3) developing tool cards to display relevant metrics and metadata, helping researchers select the right tools and allowing developers to highlight their tools' impact.In Phase 1, we refined the tool metadata schema and developed a Python-based testing infrastructure to check for documentation, testing files, and deployment on non-native Linux environments. We selected ten tools from the CCKP for initial testing, generating logs that assess their reusability. Citation Format: Aditi Gopalan, Brad Macdonald, James Eddy, Thomas Yu, Susheel Varma, Jineta Banerjee, Jineta Banerjee. Enhancing reusability and adoption of cancer research tools: Development of the Cancer Complexity Toolkit [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 1078.