Accelerated Epigenetic Aging and Prospective Morbidity and Mortality Among U.S. Veterans
Our findings suggest DunedinPACE is a biomarker of accelerated aging that is prospectively associated with chronic disease morbidity and mortality, as assessed using health records from an integrated healthcare system.
Authors
- Renate Houts (ORCID: https://orcid.org/0000-0002-1518-2631)
- Michelle F. Dennis (ORCID: https://orcid.org/0000-0003-0734-7448)
- Sandra Woolson (ORCID: https://orcid.org/0000-0002-9330-9298)
- Avshalom Caspi (ORCID: https://orcid.org/0000-0003-0082-4600)
- Benjamin Williams (ORCID: https://orcid.org/0000-0003-3274-5317)
- Livia Anderson
- Katherine S. Morris Hall (ORCID: https://orcid.org/0000-0002-9834-2011)
- Kyle J. Bourassa (ORCID: https://orcid.org/0000-0001-9372-2309)
- Melanie E. Garrett (ORCID: https://orcid.org/0000-0003-2302-6150)
- Nathan A. Kimbrel (ORCID: https://orcid.org/0000-0001-7218-1005)
- Paul A. Dennis (ORCID: https://orcid.org/0000-0002-8886-3665)
- Jennifer C. Naylor (ORCID: https://orcid.org/0000-0003-2534-8700)
- Patrick S. Calhoun (ORCID: https://orcid.org/0000-0001-6739-6634)
- Allison E. Ashley‐Koch (ORCID: https://orcid.org/0000-0001-5409-9155)
- Gregory A. Taylor (ORCID: https://orcid.org/0000-0003-1966-0917)
- Jean C. Beckham (ORCID: https://orcid.org/0000-0001-8746-8949)
- Terrie E. Moffitt (ORCID: https://orcid.org/0000-0002-8589-6760)
- Karen Sugden (ORCID: https://orcid.org/0000-0002-4076-5927)
- Lauren P. Hair
Institutions
- Duke University (US)
- King's College London (GB)
- Georgetown University (US)
- Health Services Research & Development (US)
- Geriatric Research Education and Clinical Center (US)
- Durham VA Health Care System (US)
- Duke Medical Center (US)
- Duke University Hospital (US)
Publication Details
- Journal
- The Journals of Gerontology Series A
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1093/gerona/glaf088
- Citations
- 9
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 7.25