Abstract 1034: Sleep disturbances and obesity-related cancer risk: Results from the Health Examinees Study

Abstract Background: Relationships of sleep duration, chronotype, snoring, and insomnia (initiation difficulties, fragmentation, and daytime fatigue) with obesity-related cancer risk have not been comprehensively investigated. We aimed to examine the association between sleep disturbances and obesity-related cancer risk. Methods: Participants were recruited between 2004 and 2013 and followed up through December 31, 2018. A total of 70,061 participants (2,543 incident obesity-related cancer) from the Health Examinees-Gem study were included in the present study. Cox proportional hazard models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for associations of sleep duration, chronotype, snoring, and insomnia with obesity-related cancer risk. Joint effect analyses were conducted between sleep duration and other disturbances (chronotype, snoring, and insomnia). Furthermore, nonlinear associations between sleep duration and incidence of obesity-related cancer were evaluated in restricted cubic spline analysis. Results: The median follow-up time for this study was 8 years (range, 1-11 years). Short sleep duration (<6 hours) was associated with a higher risk of obesity-related cancer in males compared to reference sleep duration (7-8 hours; adjusted HR 1.30 [95% CI 1.02-1.64]). Short sleep duration was significantly associated with obesity-related cancer risk in participants with a BMI ≥25kg/m2 (adjusted HR 1.27 [95% CI 1.02-1.57]). Joint effects were observed between short sleep duration and non-conventional chronotype (adjusted HR: 1.52, 95% CI: 1.14-2.01). Adjusted restricted cubic spline analysis demonstrated statistically significant nonlinear relationships between sleep duration and obesity-related cancer risk (P <0.001). Conclusions: Short sleep duration may serve as a risk factor for obesity-related cancer. Non-linear relationships should be further investigated. Citation Format: Sinyoung Cho, Sukhong Min, Hyobin Lee, Daehee Kang. Sleep disturbances and obesity-related cancer risk: Results from the Health Examinees Study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 1034.