Abstract 1080: Transforming cancer genomics research: A platform for integrated exploration of COSMIC resources

Abstract The Catalogue of Somatic Mutations in Cancer (COSMIC) is a vital resource for cancer genomics, offering extensive data on somatic mutations, cell lines, and mutation signatures. While the existing COSMIC dataset provides wealth of diverse, high-quality information, accessing and fully utilising it requires significant processing and expertise in data analysis. To address this, we are developing a new suite of tools to enhance COSMIC data integration, usability and exploration.The Cell Line Explorer serves as a starting point for this suite, enabling users to easily access and analyse COSMIC data related to specific cell lines. This tool integrates genetic variants with annotations and reference datasets, providing dynamic insights into clinical significance. Beyond the cell lines mutation catalogue, the platform connects to key COSMIC resources, including the Cancer Gene Census, Actionability, Cancer Mutation Census, Mutational Signatures, and COSMIC3D. This integration allows users to derive deeper insights, and easily correlate mutation data with functional impact and potential clinical significance.The tools are designed for flexibility and scalability, meeting the needs of diverse users, from computational researchers, clinicians seeking actionable insights, educators incorporating bioinformatics into their teaching, and individuals with limited bioinformatics expertise who require intuitive solutions. With its intuitive interface and robust integration of COSMIC resources, this platform lowers the barriers to access and streamline complex analyses, providing researchers with powerful tools to explore and analyse cancer genomic data at unprecedented depth. Citation Format: Helder Pedro, Zbyslaw Sondka. Transforming cancer genomics research: A platform for integrated exploration of COSMIC resources [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 1080.