Abstract 796: Incidence of depression and anxiety in kidney cancer survivors: A nationwide population-based cohort study

Abstract Depression and anxiety are highly prevalent among kidney cancer survivors, yet limited evidence exists on their cumulative incidence following kidney cancer diagnosis and their associations with the diagnosis. We conducted a nationwide, population-based retrospective cohort study using the Korean National Health Insurance and Medical Checkup Linkage Database. Adults, over 20 years, diagnosed with kidney cancer from 2010 to 2020 were included, along with age- and sex-matched non-cancer comparators. Individuals with prior cancer, depression, or anxiety were excluded. We 1) quantified the empirical risk trajectories of depression and anxiety in kidney cancer survivors for up to five years post-diagnosis, and 2) estimated the time-dependent associations between kidney cancer diagnosis and the incidence of these conditions within three post-diagnosis intervals (0-1, 1-3, and 3-5 years) using inverse-probability weighted Cox regressions. Until five years post-diagnosis, survivors (n=24, 310) consistently had a higher cumulative incidence of depression (2.8% vs 2.2%) and anxiety (3.3% vs 2.6%) compared with comparators (n=173, 471). Additionally, survivors (n=16, 049) had an increased hazard of depression (hazard ratio (HR)=1.92, 95% confidence interval (CI): 1.52-2.42) and anxiety (HR=1.63, 95% CI: 1.31-2.02) compared to comparators (n=100, 782) within the first year. During the subsequent 1-3 years, the hazard of anxiety remained increased (HR=1.32, 95% CI: 1.07-1.62). In conclusion, kidney cancer survivors experienced a higher rate of depression and anxiety, especially in the early post-diagnosis period, compared to the non-cancer population. Our findings emphasize the need for proactive prevention and management of psychiatric disorders in kidney cancer patients. Citation Format: Minji Jung, Mingyi Li, Eunjung Choo, Sukhyang Lee, David Spiegel, Mike Baiocchi, Zhengyi Deng, Jinhui Li, Marvin E. Langston, Melissa L. Bondy, Benjamin I. Chung. Incidence of depression and anxiety in kidney cancer survivors: A nationwide population-based cohort study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 796.