Factors associated with local failure after stereotactic radiation to the surgical bed of patients with a single breast cancer metastasis
Postoperative SRT provides effective local control in resected BCBM. In multivariable analysis, HER2 positivity, higher BED, and timely SRT significantly influenced outcomes, while larger tumor size and delayed treatment were negative prognostic factors. Future research should optimize dosimetric strategies and integrate systemic therapy to improve local and intracranial control.
Authors
- Ory Haisraely
- Zvi Symon (ORCID: https://orcid.org/0000-0003-0971-6921)
- Zvi R. Cohen (ORCID: https://orcid.org/0000-0002-0208-5170)
- Yaacov Richard Lawrence (ORCID: https://orcid.org/0000-0002-9959-2485)
- Marcia Jaffe
- Orit Kaidar‐Person (ORCID: https://orcid.org/0000-0003-4023-1869)
- Anton Whol
- Alicia Taliansky
- Thaila Kaisman-Elbaz
Institutions
- Tel Aviv University (IL)
- Sheba Medical Center (IL)
- Maastricht University (NL)
Publication Details
- Journal
- Acta Neurochirurgica
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1007/s00701-025-06520-9
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tel Aviv University