Comprehensive analysis of lactylation-related gene and immune microenvironment in atrial fibrillation
This study reveals a strong association between lactylation-related genes and immune infiltration in AF, suggesting their involvement in immune remodeling. The identified five-gene signature serves as a potential diagnostic biomarker set, offering novel insights into AF pathogenesis and contributing to improved diagnosis and targeted therapeutic strategies. Future studies integrating proteomic and single-cell analyses will further clarify the role of lactylation in AF.
Authors
- Yazhe Ma
- Yuanjia Ke
- Qingyan Zhao (ORCID: https://orcid.org/0000-0002-9610-2452)
- Yang Chen (ORCID: https://orcid.org/0000-0002-2808-6286)
- Youcheng Wang (ORCID: https://orcid.org/0000-0001-8199-0373)
- Jie Fan (ORCID: https://orcid.org/0009-0000-7598-6095)
Institutions
- Wuhan University (CN)
- First People's Hospital of Yunnan Province (CN)
- Songshan Lake Materials Laboratory (CN)
- Dongguan People’s Hospital (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-04-22
- DOI
- https://doi.org/10.3389/fcvm.2025.1567310
- Citations
- 3
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 4.16