Coinfection with HIV-1 skews iNKT cells toward TCR anergy and limited expansion potential in people with hepatitis C
The changes observed in iNKT phenotype and proliferative ability in people with HIV/HCV coinfection suggest an impairment that may be contributing to the enhanced pathogenesis during coinfection and could inform novel therapeutic approaches.
Authors
- M. Anthony Moody
- Grant Williams (ORCID: https://orcid.org/0000-0003-0195-524X)
- Shalini Jha (ORCID: https://orcid.org/0000-0002-9792-2161)
- Guido Ferrari (ORCID: https://orcid.org/0000-0001-7747-3349)
- Susanna Naggie (ORCID: https://orcid.org/0000-0001-7721-6975)
- S. M. White (ORCID: https://orcid.org/0000-0002-5123-5307)
- Danielle Nettere (ORCID: https://orcid.org/0000-0002-6238-1991)
- Cliburn Chan
Institutions
- Duke University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1469473
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Center for AIDS Research, University of Washington