Proteomic signatures of retinal pigment epithelium-derived exosomes in myopic and non-myopic tree shrew eyes

Using standard molecular and imaging techniques, this study provides the first demonstration of the <i>ex-vivo</i> RPE exosome biogenesis from tree shrew eyes. The results showed distinct differential expressions of the RPE exosomal proteins between the myopic and non-myopic eyes, with several proteins unique to each group. Future targeted proteomic studies of identified candidate exosomal protein signatures could elucidate the molecular mechanism of RPE exosome-mediated growth signal transmission in the emmetropization pathway.