Cerebral perfusion and gray matter volume alterations associated with cognitive impairment in metabolic syndrome with cerebral small vessel disease
CBF and GMV were strongly associated with cognitive performance. CSVD, rather than individual components of MetS, mediated cognitive impairment in patients with MetS-CSVD. CSVD likely contributes indirectly to cognitive impairment through its effects on CBF and GMV in these patients.
Authors
- Daping Lv
- Gang Zhang (ORCID: https://orcid.org/0000-0003-4305-2567)
- Xiaoqun Zhu (ORCID: https://orcid.org/0000-0001-9042-0057)
- Wenhui Zheng (ORCID: https://orcid.org/0000-0003-1426-2135)
- Yu Xia (ORCID: https://orcid.org/0000-0002-0775-007X)
- Zhongwu Sun (ORCID: https://orcid.org/0000-0002-7230-9328)
- Yan Liu (ORCID: https://orcid.org/0000-0003-4881-8429)
- Han Liu
- Jie Geng
- Xia Zhou (ORCID: https://orcid.org/0000-0002-4037-6809)
Institutions
- Shanghai Jiao Tong University (CN)
- Anhui Medical University (CN)
- Tongren Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- The Second Affiliated Hospital of Bengbu Medical College (CN)
- Anhui Mental Health Center (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-04-22
- DOI
- https://doi.org/10.3389/fnagi.2025.1538850
- Citations
- 3
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.53
Funders
- National Natural Science Foundation of China
- Anhui University
- Anhui Medical University
- Natural Science Foundation of Anhui Province