Scorpion venom peptides enhance immunity and survival in Litopenaeus vannamei through antibacterial action against Vibrio parahaemolyticus
The amphipathic α-helical structure of these peptides is fundamental to their membrane-disruptive activity. The enhanced outer membrane targeting of BmKn2-7 likely correlates with structural modifications that optimize hydrophobicity and charge distribution. The differential efficacy in immune regulation, such as BmKn2-7's broad pathway activation versus BmKn1's selective ROS induction, indicates structure-dependent functional divergence. These findings highlight the potential of tailored scorpion venom peptides as dual-action agents against bacterial infections and immune dysregulation.
Authors
- Ling Zeng (ORCID: https://orcid.org/0000-0002-9516-4635)
- Yulin Sun (ORCID: https://orcid.org/0000-0001-9917-0269)
- Ran Du (ORCID: https://orcid.org/0000-0002-6647-0780)
- Xiangxi Yi (ORCID: https://orcid.org/0000-0002-8251-8836)
- Qi Wang (ORCID: https://orcid.org/0000-0002-5287-6050)
- Hualin Zhang (ORCID: https://orcid.org/0009-0001-0980-3817)
- Ziming Chen (ORCID: https://orcid.org/0009-0005-2398-8466)
Institutions
- Guangxi University (CN)
- Lingnan Normal University (CN)
- Guangxi University of Chinese Medicine (CN)
- Guangdong Ocean University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1551816
- Citations
- 5
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 5.92
Funders
- Natural Science Foundation of Shenzhen City