The hypoxic microenvironment of Candida albicans biofilms shapes neutrophil responses
These findings provide novel insights into the impact of biofilm-induced hypoxia on neutrophil responses, identifying HIF-1α as a key regulator of immune adaptation in fungal biofilms. Targeting hypoxia pathways may offer new therapeutic strategies to modulate neutrophil responses and enhance host defenses against fungal infections.
Authors
- Magdalena Juszczak (ORCID: https://orcid.org/0000-0003-1335-6615)
- Marcin Zawrotniak (ORCID: https://orcid.org/0000-0003-4795-7937)
- Maria Rąpała‐Kozik (ORCID: https://orcid.org/0000-0002-3225-7391)
- Aleksandra Brankiewicz (ORCID: https://orcid.org/0000-0002-0065-9142)
Institutions
- Jagiellonian University (PL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1547559
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Uniwersytet Jagielloński w Krakowie