Mucosal Microbiome Markers of Complete Pathologic Response to Neoadjuvant Therapy in Rectal Carcinoma
Posttreatment markers of the complete response of rectal carcinoma to neoadjuvant chemoradiation are needed to guide decisions about surgical resection. We found that mucosal microbiome β diversity, bacterial metabolic capacities, and specific taxonomic groups distinguished between complete and incomplete responders. The mucosal microbiome provides markers for complete pathologic response.
Authors
- Amr H. Masaadeh (ORCID: https://orcid.org/0000-0003-1614-1628)
- Ibrahim Abukhiran (ORCID: https://orcid.org/0000-0002-1271-4110)
- James D. Byrne (ORCID: https://orcid.org/0000-0002-6436-2866)
- Dustin E. Bosch (ORCID: https://orcid.org/0000-0002-7430-2939)
Institutions
- University of Iowa (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0036
- Citations
- 2
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Institutes of Health
- Holden Comprehensive Cancer Center, University of Iowa
- National Cancer Institute