Pathological complete response after monotherapy with immune checkpoint inhibitors for bifocal colon cancer in a patient with lynch syndrome and situs inversus totalis: a case report
The anatomical variations associated with SIT increase the complexity of surgical procedures. Advanced imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI) are essential for assessing fine anatomical details and facilitating surgery. ICIs are an effective treatment option for Lynch syndrome-associated CRC, as demonstrated in this case. Future studies should investigate the optimal timing of immunotherapy, combination treatment strategies, and methods to mitigate immune-related toxicities. Such research will help develop comprehensive and personalized treatment plans for Lynch syndrome-associated CRC.
Authors
- Yuanyi Ding (ORCID: https://orcid.org/0009-0006-5566-675X)
- Jun Feng (ORCID: https://orcid.org/0000-0003-0317-7613)
- Jianfeng Zhang (ORCID: https://orcid.org/0000-0002-3270-0533)
- Juan Zhang (ORCID: https://orcid.org/0000-0003-1780-8340)
- Fangfang Wang (ORCID: https://orcid.org/0000-0002-5441-4490)
- Zheng Li (ORCID: https://orcid.org/0000-0002-8837-0318)
- Bin Yu (ORCID: https://orcid.org/0000-0002-8827-1256)
- Chenhui Li (ORCID: https://orcid.org/0000-0003-3158-9869)
- Guiying Wang (ORCID: https://orcid.org/0000-0002-8743-325X)
- Baokun Li (ORCID: https://orcid.org/0000-0003-1502-6273)
- Wenbo Niu (ORCID: https://orcid.org/0009-0000-6983-9814)
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1571607
- Citations
- 2
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.94