MIF tautomerase inhibitor TE-11 prevents inflammatory macrophage activation and glycolytic reprogramming while reducing leukocyte migration and improving Crohn’s disease-like colitis in male mice
Comprehensively, TE-11, a MIF tautomerase inhibitor ameliorates CD-like colitis, reduces MIF-induced eosinophil and neutrophil migration and prevents M1 polarization and associated metabolic reprogramming; therefore, it may prove beneficial as a potential drug candidate regarding CD therapy.
Authors
- Eva M. Sturm (ORCID: https://orcid.org/0000-0003-4898-884X)
- Lilla Makszin (ORCID: https://orcid.org/0000-0002-9764-4763)
- Péter Deák (ORCID: https://orcid.org/0000-0002-8849-0352)
- Nikoletta Kálmán (ORCID: https://orcid.org/0000-0001-6827-9894)
- Eszter Vámos (ORCID: https://orcid.org/0000-0003-0622-442X)
- Viola Bagóné Vántus (ORCID: https://orcid.org/0000-0001-7557-3004)
- Balázs Radnai (ORCID: https://orcid.org/0000-0002-7147-0080)
- Tamás Lóránd (ORCID: https://orcid.org/0000-0002-0599-0758)
- Ferenc Gallyas (ORCID: https://orcid.org/0000-0002-1906-4333)
- Barsha Baisakhi Nayak (ORCID: https://orcid.org/0000-0002-1441-8681)
Institutions
- Medical University of Graz (AT)
- University of Pecs (HU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1558079
- Citations
- 1
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Austrian Science Fund
- Nemzeti Kutatási, Fejlesztési és Innovaciós Alap