Direct mechanical thrombectomy vs. intravenous alteplase plus mechanical thrombectomy in acute ischemic stroke with anterior circulation tandem occlusions
This study found no evidence that prior intravenous thrombolysis affects clinical or imaging outcomes in patients with acute ischemic stroke due to anterior circulation tandem occlusions after endovascular thrombectomy. Bridging therapy may be associated with an increased rate of aSICH. Intraprocedural tirofiban administration, stent implantation, and a lower baseline NIHSS score were associated with favorable outcomes.
Authors
- Huaizhang Shi (ORCID: https://orcid.org/0000-0003-3150-6234)
- Qiaowei Wu (ORCID: https://orcid.org/0000-0001-9454-1411)
- Yujing Zhu (ORCID: https://orcid.org/0000-0002-0045-6708)
- Guang Zhang (ORCID: https://orcid.org/0000-0003-1589-3502)
- Shancai Xu (ORCID: https://orcid.org/0000-0002-1111-2409)
- Zhonghui Yang
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Surgery
- Published
- 2025-04-22
- DOI
- https://doi.org/10.3389/fsurg.2025.1536912
- Citations
- 1
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Harbin Medical University
- Natural Science Foundation of Guangxi Province
- National Health Commission of the People's Republic of China