METTL1-driven nucleotide metabolism reprograms the immune microenvironment in hepatocellular carcinoma: a multi-omics approach for prognostic biomarker discovery
This study highlights the innovative role of METTL1-driven nucleotide metabolism reprogramming in reshaping the immune microenvironment of HCC. The findings provide novel insights into HCC pathogenesis and pave the way for developing personalized therapeutic strategies based on targeting METTL1 and its associated metabolic pathways.
Authors
- Fuli Xie
- Yangyue Huang
- Qiaohua Zhu (ORCID: https://orcid.org/0000-0001-8702-8900)
- Zhen Fu (ORCID: https://orcid.org/0000-0002-8120-590X)
- Xie Weng
- Xingli Liu (ORCID: https://orcid.org/0009-0009-1063-5265)
- Dayong Zheng (ORCID: https://orcid.org/0000-0001-7975-8946)
- Jiale Wang (ORCID: https://orcid.org/0009-0006-3817-6644)
Institutions
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1582203
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Natural Science Foundation of Xinjiang Province
- National Natural Science Foundation of China