Host-mimicking conditions promote Pseudomonas aeruginosa PA14 virulence gene expression
Overall, our findings support using host-mimicking conditions to improve the expression of candidate targets for anti-virulence therapeutics against <i>P. aeruginosa</i> PA14 in a planktonic state. These recommendations may be broadly applicable for antivirulence therapeutic screening against multiple bacterial species at large.
Authors
- Amber Grace
- Rajnish Sahu (ORCID: https://orcid.org/0000-0001-6270-2946)
- Vida A. Dennis (ORCID: https://orcid.org/0000-0003-1409-5605)
- Donald R. Owen
Institutions
- Alabama State University (US)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.3389/fmicb.2025.1557664
- Citations
- 9
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- National Science Foundation
- Eli Lilly and Company
- Alabama State University
- National Institutes of Health
- National Institute of General Medical Sciences