Mechanism of Ershen Zhenwu Decoction in ameliorating chronic heart failure via JNK/MAPK-regulated apoptosis: insights from network pharmacology and experimental validation
Our study shows that paeoniflorin, acetylaconitine, and cryptotanshinone bind to key proteins in the JNK/MAPK apoptosis pathway. <i>In vitro</i> validation confirms drug serum from ESZWD regulates this pathway, supporting its therapeutic potential for CHF.
Authors
- Maomao Zhang (ORCID: https://orcid.org/0009-0009-9451-5446)
- Zhenpeng Zhu (ORCID: https://orcid.org/0000-0003-4283-310X)
- Yulong Liu (ORCID: https://orcid.org/0000-0002-7920-4633)
- Xiaoyu Cheng (ORCID: https://orcid.org/0000-0001-5413-2859)
- Lan Ge (ORCID: https://orcid.org/0000-0001-8692-3225)
- Xinyue Wang (ORCID: https://orcid.org/0000-0002-5837-5361)
- Dan Cheng
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-04-22
- DOI
- https://doi.org/10.3389/fcvm.2025.1561963
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00