FOXO1 mediates miR-99a-5p/E2F7 to restrain breast cancer cell proliferation and induce apoptosis
FOXO1 suppresses breast cancer cell proliferation and promotes apoptosis by enhancing the transcription and expression of miR-99a-5p, while inhibiting its target gene E2F7. E2F7, in turn, represses the transcription of FOXO1, lowering its expression.
Authors
- Ying Zhang (ORCID: https://orcid.org/0000-0001-8065-3519)
- Yiliang Wang (ORCID: https://orcid.org/0000-0003-2039-7132)
- Bo Ma (ORCID: https://orcid.org/0000-0003-1322-6159)
- Haili Wang (ORCID: https://orcid.org/0000-0002-0310-8143)
Institutions
- Liaoning Provincial People's Hospital (CN)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1186/s12885-025-14111-1
- Citations
- 5
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 4.03