Desensitization With Proteasome Inhibition and Costimulation Blockade Modulates the Xenoreactive Humoral Response in Nonhuman Primate Xenotransplantation
A structured desensitization regimen including proteasome inhibition and costimulation blockade results in plasma cell depletion and resultant reduction in circulating xenoreactive anti-pig IgG antibodies, with a modest improvement in xenograft survival. This desensitization regimen has promise for pig-to-NHP xenotransplant models.
Authors
- David A. Faber
- Brendan P. Lovasik (ORCID: https://orcid.org/0000-0002-3770-2079)
- Alton B. Farris (ORCID: https://orcid.org/0000-0001-5534-7763)
- A. Joseph Tector (ORCID: https://orcid.org/0000-0002-9865-8382)
- Cynthia Breeden (ORCID: https://orcid.org/0000-0001-8716-4435)
- Andrew B. Adams (ORCID: https://orcid.org/0000-0001-8925-9956)
- Jakob Habib (ORCID: https://orcid.org/0000-0002-8720-8757)
- Abraham J. Matar (ORCID: https://orcid.org/0000-0001-7351-7674)
Institutions
- University of Minnesota (US)
- University of Miami (US)
- Emory University (US)
- Washington University in St. Louis (US)
Publication Details
- Journal
- Xenotransplantation
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1111/xen.70045
- Citations
- 2
- Primary Topic
- Xenotransplantation and immune response
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases