UTILIZE MPV, PDW, AND P-LCR AS PREDICTIVE MARKERS FOR THE EARLY DETECTION OF DIABETES MELLITUS COMPLICATIONS.

Diabetes Mellitus, one of the oldest and most widespread diseases globally, poses a significant risk due to its association with an unstable thrombogenic state resulting from impaired platelet and endothelial function, coagulation, and fibrinolysis. This cross-sectional, observational study conducted over one year (January to December 2024) at the Pathology Department of Santosh Medical College involved 152 Type 2 Diabetes Mellitus patients, with a male-to-female ratio of 1.5:1 and a majority aged between 41–50 years. The study aimed to evaluate mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (P-LCR) as predictive markers for early detection of diabetic complications. Results demonstrated a significant association between these platelet indices and diabetic complications (p < 0.001), and a strong correlation with HbA1c levels through Pearson correlation analysis. These findings suggest that regular monitoring of MPV, PDW, and P-LCR may aid in the early detection and prevention of microvascular complications in diabetic patients, potentially averting severe outcomes.