SGLT2 inhibitor in a type 2 diabetes mellitus patient coexisted with central diabetes insipidus following hyperosmolar hyperglycemic state
This case highlights that SGLT2 inhibitors, such as dapagliflozin, may accelerate polyuria and alter urine osmolality by inhibiting glucose and sodium reabsorption in the proximal tubular. Therefore, it is crucial to discontinue SGLT2 inhibitors when CDI is suspected or diagnosed.
Authors
- Shu Liu (ORCID: https://orcid.org/0000-0003-4013-5295)
- Bingyin Shi
- Yanru Zhao (ORCID: https://orcid.org/0000-0001-9934-8290)
- Hui Guo (ORCID: https://orcid.org/0000-0001-9780-0845)
- Wenqiang Chen (ORCID: https://orcid.org/0000-0002-0350-1383)
- Shaohui Ma (ORCID: https://orcid.org/0009-0006-8087-0277)
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- BMC Endocrine Disorders
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1186/s12902-025-01924-1
- Citations
- 4
- Primary Topic
- Electrolyte and hormonal disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.07