Astilbin from Smilax china L. remarkably inhibits LPS-induced endometritis in rats via blocking positive feedback between TLR4 and IL-6R signalling pathways in a PPAR-γ-dependent manner
Overall, our results demonstrated that ATB can significantly inhibit endometritis in rats, presumably through interfering with NF-κB and STAT3 signal transduction in a PPAR-γ-dependent manner, blocking the positive feedback between NF-κB and STAT3 signalling. Our findings provide new evidences for developing the ATB, the main compound identified from FSCR, as a potential therapeutic agent for endometritis.
Authors
- Chunni Li
- Wenqin Liu (ORCID: https://orcid.org/0009-0009-1200-781X)
- Chuqi Hou (ORCID: https://orcid.org/0000-0002-9125-9661)
- Haixing Feng (ORCID: https://orcid.org/0000-0002-6580-3280)
- Zhiwen Li (ORCID: https://orcid.org/0000-0003-2970-5832)
- Lianbing Hou (ORCID: https://orcid.org/0000-0001-7256-0996)
- Jingyao Chen (ORCID: https://orcid.org/0000-0002-4934-7983)
- Chunxia Wang (ORCID: https://orcid.org/0000-0001-5872-6312)
- Xuan Ye
Institutions
- Nanfang Hospital (CN)
- Shenzhen University Health Science Center (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1016/j.jep.2025.119861
- Citations
- 3
- Primary Topic
- Seaweed-derived Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 6.82