Population Pharmacokinetic Modelling of Remdesivir and Its Metabolite GS-441524 in Hospitalised Patients with COVID-19
The licensed remdesivir dose may achieve target concentrations of GS-441524, but higher dosages may optimise outcomes. Dose adjustments are guided primarily by kidney function.
Authors
- Sara Christensen Holz (ORCID: https://orcid.org/0000-0002-7488-7287)
- David Bowen (ORCID: https://orcid.org/0000-0003-2294-2544)
- Indy Sandaradura (ORCID: https://orcid.org/0000-0002-9457-8262)
- Saurabh Pandey (ORCID: https://orcid.org/0000-0003-0871-1504)
- Adam G. Stewart (ORCID: https://orcid.org/0000-0002-7262-7529)
- Anthony Byrne (ORCID: https://orcid.org/0000-0002-1413-1496)
- Krispin Hajkowicz (ORCID: https://orcid.org/0000-0001-6990-0486)
- Darren M. Roberts (ORCID: https://orcid.org/0000-0001-9101-7577)
- Jason A. Roberts (ORCID: https://orcid.org/0000-0001-6218-435X)
- Vincent Seah
- Hergen Buscher (ORCID: https://orcid.org/0000-0002-4531-6151)
- Steven C. Wallis (ORCID: https://orcid.org/0000-0002-2392-9854)
- Bridin Murnion (ORCID: https://orcid.org/0000-0001-7791-3025)
- Andrew Burke
- Jane Ellen Carland (ORCID: https://orcid.org/0000-0002-1456-876X)
- Suzanne L. Parker (ORCID: https://orcid.org/0000-0002-6124-7475)
- Chandra Datta Sumi (ORCID: https://orcid.org/0000-0003-4553-7525)
- Xin Liu (ORCID: https://orcid.org/0000-0002-6210-8100)
- James M. Peek
Institutions
- The University of Sydney (AU)
- Queensland Health (AU)
- The University of Queensland (AU)
- Université de Montpellier (FR)
- Royal Brisbane and Women's Hospital (AU)
- Royal Prince Alfred Hospital (AU)
- Westmead Hospital (AU)
- St Vincent's Hospital Sydney (AU)
- Metro South Health (AU)
- St Vincent's Health (AU)
- St Vincent’s Private Hospital Sydney (AU)
- St Vincent's Clinic (AU)
- Prince Charles Hospital (AU)
- Westmead Institute (AU)
- Université de Nîmes (FR)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1007/s40262-025-01496-2
- Citations
- 1
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Queensland Health
- Australian and New Zealand Society of Nephrology
- University of Queensland
- Prince Charles Hospital Foundation
- National Health and Medical Research Council