Population Pharmacokinetic Modelling of Remdesivir and Its Metabolite GS-441524 in Hospitalised Patients with COVID-19

The licensed remdesivir dose may achieve target concentrations of GS-441524, but higher dosages may optimise outcomes. Dose adjustments are guided primarily by kidney function.

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Publication Details

Journal
Clinical Pharmacokinetics
Published
2025-04-22
DOI
https://doi.org/10.1007/s40262-025-01496-2
Citations
1
Primary Topic
COVID-19 Clinical Research Studies
Type
article
Field-Weighted Citation Impact
1.40

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article

Population Pharmacokinetic Modelling of Remdesivir and Its Metabolite GS-441524 in Hospitalised Patients with COVID-19

Sara Christensen Holz, David Bowen, Indy Sandaradura, Saurabh Pandey et al.
1 citations
Clinical Pharmacokinetics
COVID-19 Clinical Research Studies
1.40
article

Population Pharmacokinetic Modelling of Remdesivir and Its Metabolite GS-441524 in Hospitalised Patients with COVID-19

Sara Christensen Holz, David Bowen, Indy Sandaradura, Saurabh Pandey, Adam G. Stewart, Anthony Byrne, Krispin Hajkowicz, Darren M. Roberts, Jason A. Roberts, Vincent Seah, Hergen Buscher, Steven C. Wallis, Bridin Murnion, Andrew Burke, Jane Ellen Carland, Suzanne L. Parker, Chandra Datta Sumi, Xin Liu, James M. Peek
article en
1 citations

Abstract

The licensed remdesivir dose may achieve target concentrations of GS-441524, but higher dosages may optimise outcomes. Dose adjustments are guided primarily by kidney function.

Clinical PharmacokineticsVol. 64(5)
The University of Sydney (AU), Queensland Health (AU), The University of Queensland (AU), Université de Montpellier (FR), Royal Brisbane and Women's Hospital (AU), Royal Prince Alfred Hospital (AU), Westmead Hospital (AU), St Vincent's Hospital Sydney (AU), Metro South Health (AU), St Vincent's Health (AU), St Vincent’s Private Hospital Sydney (AU), St Vincent's Clinic (AU), Prince Charles Hospital (AU), Westmead Institute (AU), Université de Nîmes (FR)
Queensland Health, Australian and New Zealand Society of Nephrology, University of Queensland, Prince Charles Hospital Foundation, National Health and Medical Research Council
Good health and well-being
Openalex Percentile: Top 22%
COVID-19 Clinical Research Studies
1.40
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